Clavulanate potassium is a potent β-lactamase inhibitor and acts as an antibiotic. Potassium clavulanate is an enzyme inhibitor with broad enzyme inhibitory spectrum, strong enzyme inhibitory effect and good cell membrane permeability. It has a strong inhibitory effect on almost all β-lactamases, including penicillinase, broad-spectrum enzymes and extended-spectrum enzymes that can inactivate third-generation cephalosporins, especially for plasmid-mediated β-lactamases.
This product is supplied as Potassium Clavulanate-Microcrystalline cellulose(1:1) form.
| Molecular Weight | 239.27 |
| Formula | C8H10KNO5 |
| CAS Number | 61177-45-5 |
| Solubility (25°C) | Water ≥ 20 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Chee Wei Tan, et al. Singapore Med J. Urinary tract infections in adults
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