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CINPA1

Cat. No. M14673

All AbMole products are for research use only, cannot be used for human consumption.

CINPA1 Structure

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Quality Control & Documentation
Biological Activity

CINPA1 is a potent and specific inhibitor of constitutive androstane receptor (CAR) that does not activate pregnane X receptor (PXR). CINPA1 reduces CAR-mediated transcription with an IC50 of ~70 nM. CINPA1 can be used as a molecular tool for understanding CAR function.

Chemical Information
Molecular Weight 395.49
CAS Number 102636-74-8
Solubility (25°C) DMSO 150 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Milu T Cherian, et al. CINPA1 binds directly to constitutive androstane receptor and inhibits its activity

[2] Judith Jeske, et al. Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor

[3] Milu T Cherian, et al. Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor

[4] Wenwei Lin, et al. Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor

[5] Milu T Cherian, et al. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor

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  Catalog
Abmole Inhibitor Catalog




Keywords: CINPA1 supplier, inhibitors, activators

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