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Cinnamoylglycine

Cat. No. M21460
Cinnamoylglycine  Structure
Size Price Availability Quantity
10mg USD 48  USD48 In stock
50mg USD 115  USD115 In stock
250mg USD 238  USD238 In stock
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Quality Control & Documentation
Biological Activity

Cinnamoylglycine is a human urine metabolite, a glycine conjugate of cinnamic acid and. Cinnamoylglycine is used as a urine marker, which can be used as a marker for colonization of drug resistance after the antibiotic study period.

Chemical Information
Molecular Weight 205.21
Formula C11H11NO3
CAS Number 16534-24-0
Solubility (25°C) DMSO : 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vera Wewer, et al. Parasit Vectors. Urine metabolites for the identification of Onchocerca volvulus infections in patients from Cameroon

[2] Ting Zhang, et al. Zhongguo Zhong Yao Za Zhi. [UPLC-Q-TOF-MS-based metabolomics study of celastrol]

[3] Astrid M Suchy-Dicey, et al. J Am Soc Nephrol. Tubular Secretion in CKD

[4] Michael S Lustgarten, et al. Med Sci Sports Exerc. Analytes and Metabolites Associated with Muscle Quality in Young, Healthy Adults

[5] Benjamin Lidgard, et al. J Am Soc Nephrol. Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function

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