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CID 16020046

Cat. No. M13987

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CID 16020046 Structure
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Biological Activity

CID 16020046 is a potent and selective GPR55 antagonist and inhibits GPR55 constitutive activity with an IC50 of 0.15 μM. CID 16020046 inhibits GPR55-mediated Ca2+ signaling and GPR55-mediated ERK1/2 phosphorylation. CID 16020046 reduces wound healing in endothelial cells and is involved in the regulation of platelet function.

Chemical Information
Molecular Weight 425.44
CAS Number 834903-43-4
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Katrina Hurst, et al. A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity

[2] Neha Munawar, et al. Antihyperalgesic Activities of Endocannabinoids in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

[3] Yousuf M Al Suleimani, et al. The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant

[4] Nagendra S Singh, et al. Selective GPR55 antagonism reduces chemoresistance in cancer cells

[5] Y M AlSuleimani, et al. The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells

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Keywords: CID 16020046 supplier, inhibitors, activators

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