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Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier.
| Molecular Weight | 313.4 |
| Formula | C17H23N5O |
| CAS Number | 1613480-70-8 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] David S Schade, et al. Endocr Pract. Cholesterol Review: A Metabolically Important Molecule
[4] Jie Luo, et al. Nat Rev Mol Cell Biol. Mechanisms and regulation of cholesterol homeostasis
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