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Chlorsulfuron 

Cat. No. M30427
Chlorsulfuron  Structure
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Quality Control & Documentation
Biological Activity

Chlorsulfuron blocks the biosynthesis of the amino acids valine and isoleucine in plants. Chlorsulfuron completely alleviates herbicide-induced growth inhibition. The site of action of Chlorsulfuron is the enzyme acetolactate synthase.

Chemical Information
Molecular Weight 357.77
Formula C12H12ClN5O4S
CAS Number 64902-72-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alexandra Casey, et al. Pestic Biochem Physiol. Transcriptome changes in chlorsulfuron-treated plants are caused by acetolactate synthase inhibition and not induction of a herbicide detoxification system in Marchantia polymorpha

[2] Lei Wu, et al. Molecules. Alkaline Soil Degradation and Crop Safety of 5-Substituted Chlorsulfuron Derivatives

[3] Lei Wu, et al. Molecules. Degradation of 5-Dialkylamino-Substituted Chlorsulfuron Derivatives in Alkaline Soil

[4] Balaji Aravindhan Pandian, et al. Planta. A single gene inherited trait confers metabolic resistance to chlorsulfuron in grain sorghum (Sorghum bicolor)

[5] T Winder, et al. Mol Gen Genet. Imazaquin and chlorsulfuron resistance and cross resistance in mutants of Chlamydomonas reinhardtii

Related ALS Products
Foramsulfuron

Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.).

Nicosulfuron

Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity.

Imazamox

Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death.

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Keywords: Chlorsulfuron  supplier, ALS, inhibitors, activators


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