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Chlortetracycline is a broad-spectrum antibiotic tetracycline with a 7-chloro substitution. It inhibits growth of both Gram-negative and Gram-positive bacteria by inhibiting protein synthesis.
In vitro: Chlortetracycline enhances E2 production in vitro in H295R cells consistent with increased aromatase activity and enhanced expression of CYP17, CYP19, and 3βHSD2 mRNAs. Chlortetracycline increases aromatase activity.
In vivo: Chlortetracycline enhances E2 production in vivo in male medaka fish.
| Cell Experiment | |
|---|---|
| Cell lines | H295R cells |
| Preparation method | - |
| Concentrations | 0, 0.02, 0.2, 2, 20 mg/L |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 478.88 |
| Formula | C22H23ClN2O8 |
| CAS Number | 57-62-5 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| N-Hydroxypipecolic acid
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