All AbMole products are for research use only, cannot be used for human consumption.
Chikusetsusaponin IVa a major active ingredient of triterpenoid saponins, exerts antithrombotic effects, including minor hemorrhagic events. This appears to be important for the development of new therapeutic agents. a novel AMPK activator that is capable of bypassing defective insulin signalling and could be useful for the treatment of T2DM or other metabolic disorders. IC50 Value: 199.4 ± 9.1 μM (inhibiting thrombin-induced fibrinogen clotting) Target: In vitro: Using biochemical and pharmacological methods, it proves that chikusetsusaponin IVa prolongs the recalcification time, prothrombin time, activated partial thromboplastin time, and thrombin time of normal human plasma in a dose-dependent manner; inhibits the amidolytic activity of thrombin and factor Xa upon synthetic substrates S2238 and S2222; inhibits thrombin-induced fibrinogen clotting (50% inhibition concentration, 199.4 ± 9.1 μM); inhibits thrombin- and collagen-induced platelet aggregation. Chikusetsusaponin IVa can also preferentially inhibits thrombin in a competitive manner (K(i)=219.6 μM). Chikusetsusaponin IVa suppresses the production of iNOS, COX-2, IL-1β, IL-6, and TNF-α in LPS-stimulated THP-1 cells likely by inhibiting NF-κB activation and ERK, JNK, and p38 signal pathway phosphorylation. In vivo: Studies were performed on type 2 diabetic mellitus (T2DM) rats given CHS for 28 days to test the antihyperglycemic activity. Oral administration of CHS dose-dependently increased the level of serum insulin and decreased the rise in blood glucose level.
| Molecular Weight | 794.97 |
| CAS Number | 51415-02-2 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Jun Yin, et al. Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds
| Related Others Products |
|---|
| 4-O-Galloylalbiflorin
4-O-Galloylalbiflorin is a natural product that can be derived from the root of Paeonia lactiflora pall. |
| Licoricesaponin E2
Licoricesaponin E2 is a triterpene saponinthat can be found in Glycyrrhiza inflata. |
| Uralsaponin B
Uralsaponin B is a natural product. |
| Daturataturin A aglycone
Daturataturin A aglycone is a natural Steroids isolated from the herbs of Datura tatura. Daturataturin A aglycone can be used for research related to life sciences. |
| (4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al
(4→2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al is extracted from the unripe fruits of Polyalthia longifolia var. pendula. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
