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CGS-9343B

Cat. No. M7695

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CGS-9343B Structure

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Quality Control & Documentation
Biological Activity

CGS-9343B is a selective calmodulin antagonist with minimal protein kinase C or antidopaminergic activity. CGS-9343B is a potent inhibitor of calmodulin-activated (Type I) phosphodiesterase activity with IC50 in the nanomolar range.

Chemical Information
Molecular Weight 544.6
Formula C26H28N4O2 · C4H4O4
CAS Number 109826-27-9
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hongliang Li, et al. The calmodulin inhibitor CGS 9343B inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells

[2] J A Norman, et al. CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity

[3] J E Shook, et al. Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea

[4] H Safayhi, et al. CGS 9343B and W7 (calmodulin antagonists) inhibit KCl-induced increase in cytosolic free calcium and insulin secretion of RINm5F cells

[5] R N Fedorak, et al. Inhibition of cholera-toxin-stimulated intestinal secretion by CGS 9343B in rats: a specific calmodulin inhibitor

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  Catalog
Abmole Inhibitor Catalog




Keywords: CGS-9343B supplier, inhibitors, activators

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