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CGS-9343B is a selective calmodulin antagonist with minimal protein kinase C or antidopaminergic activity. CGS-9343B is a potent inhibitor of calmodulin-activated (Type I) phosphodiesterase activity with IC50 in the nanomolar range.
| Molecular Weight | 544.6 |
| Formula | C26H28N4O2 · C4H4O4 |
| CAS Number | 109826-27-9 |
| Solubility (25°C) | DMSO: ≥10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] J A Norman, et al. CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity
[3] J E Shook, et al. Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea
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