All AbMole products are for research use only, cannot be used for human consumption.
Cetilistat is highly lipophilic, which facilitated their dissolution in the GTL without the need of a vehicle. Although cetilistat is a benzoxazinone lipase inhibitor, orlistat reacts with the nucleophilic serine of lipases via its β-lactone moiety, resulting in a covalent complex.
| Cell Experiment | |
|---|---|
| Cell lines | acinar cells |
| Preparation method | Pancreatic acini were harvested and preincubated with 50 μmol/L orlistat or cetilistat, after which linoleic acid (LA) or GTL was added, followed by incubation for 4 hours. |
| Concentrations | 50 μmol/L |
| Incubation time | 4 h |
| Animal Experiment | |
|---|---|
| Animal models | Wistar rats |
| Formulation | GTL |
| Dosages | 25 mg/mL |
| Administration | i.v. |
| Molecular Weight | 401.58 |
| Formula | C25H39NO3 |
| CAS Number | 282526-98-1 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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