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Cenerimod

Cat. No. M7560
Cenerimod Structure
Synonym:

ACT-334441

Size Price Availability Quantity
5mg USD 180  USD200 In stock
10mg USD 297  USD330 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Wistar rats
Formulation 100% DMSO
Dosages 10 mg/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 453.53
Formula C25H31N3O5
CAS Number 1262414-04-9
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties.
Piali L, et al. Pharmacol Res Perspect. 2017 Dec;5(6). PMID: 29226621.

Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P₁ Receptor Modulator in Healthy Subjects.
Juif PE, et al. Int J Mol Sci. 2017 Dec 6;18(12). PMID: 29211013.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cenerimod, ACT-334441 supplier, S1P Receptor, inhibitors

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