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Celite

Cat. No. M42806
Celite Structure
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Biological Activity

Celite can be used as an excipient, such as filter media, adsorbent.

Chemical Information
CAS Number 61790-53-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiankui Cheng et al. Environ Sci Pollut Res Int. Preparation and evaluation of celite decorated iron nanoparticles for the sequestration performance of hexavalent chromium from aqueous solution

[2] Neha Abbasi et al. J Environ Manage. Natural deep eutectic solvent (fructose-glycine) functionalized-celite/ polyethylene glycol hydrogel nanocomposite for phosphate adsorption: Statistical analysis

[3] Adrianus J De Vries et al. Interact Cardiovasc Thorac Surg. The activated clotting time in cardiac surgery: should Celite or kaolin be used?

[4] E G Pivalizza et al. J Clin Anesth. Celite-activated thrombelastography in children

[5] P Feindt et al. Thorac Cardiovasc Surg. Celite and kaolin produce differing activated clotting times during cardiopulmonary bypass under aprotinin therapy

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Keywords: Celite supplier, inhibitors, activators

 
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