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Cefotaxime

Cat. No. M10232
Cefotaxime Structure
Synonym:

Cefotaxima acid

Size Price Availability Quantity
100mg USD 30  USD30 In stock
500mg USD 70  USD70 In stock
1g USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Cefotaxime is an inhibitor of penicillin binding protein. Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6. The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens.

Chemical Information
Molecular Weight 455.47
Formula C16H17N5O7S2
CAS Number 63527-52-6
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hee-Chang Jang, et al. PLoS One. In vivo efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus sepsis

[2] John G Gums, et al. Ann Pharmacother. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies

[3] R N Jones. Diagn Microbiol Infect Dis. Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: a review

[4] A A Carmine, et al. Drugs. Cefotaxime. A review of its antibacterial activity, pharmacological properties and therapeutic use

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