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Cefodizime

Cat. No. M19931
Cefodizime Structure
Synonym:

CEF; CDZ

Size Price Availability Quantity
10mg USD 50  USD50 In stock
50mg USD 75  USD75 In stock
100mg USD 103  USD103 In stock
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Quality Control & Documentation
Biological Activity

Cefodizime (CEF, CDZ) is an aminothiazolyl cephalosporin with a broad spectrum of antibacterial activity.

Chemical Information
Molecular Weight 584.67
Formula C20H20N6O7S4
CAS Number 69739-16-8
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] C J Soussy, et al. J Antimicrob Chemother. The in-vitro activity of cefodizime: a review

[2] K Matsumoto. Jpn J Antibiot. [Cefodizime]

[3] H Knothe, et al. Infection. In vitro activity of cefodizime

[4] D Brockmeier, et al. Infection. Pharmacokinetic profile of cefodizime

[5] L B Barradell, et al. Drugs. Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use

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Keywords: Cefodizime, CEF; CDZ supplier, Anti-infection, inhibitors, activators


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