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Cefodizime Sodium

Cat. No. M19887
Cefodizime Sodium Structure
Size Price Availability Quantity
10mg USD 48  USD48 In stock
50mg USD 76  USD76 In stock
100mg USD 102  USD102 In stock
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Quality Control & Documentation
Biological Activity

Cefodizime Sodium, a third generation cephalosporin antibiotic, has broad-spectrum activity and is stable to most beta-lactamases.

Chemical Information
Molecular Weight 628.63
Formula C20H18N6Na2O7S4
CAS Number 86329-79-5
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M Merighi, et al. J Chemother. Stability of cefodizime in solution and compatibility with other injectable drugs

[2] O Yamakita, et al. J Toxicol Sci. [Local irritation studies of cefodizime sodium]

[3] M Takemoto, et al. J Toxicol Sci. [Antigenicity test of cefodizime sodium]

[4] T Kitatani, et al. J Toxicol Sci. [Teratological study of cefodizime sodium in mice--intravenous administration during period of organogenesis]

[5] A Ohuchida, et al. J Toxicol Sci. Mutagenicity test of cefodizime sodium

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