Cefixime is a broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins
Molecular Weight | 453.45 |
Formula | C16H15N5O7S2 |
CAS Number | 79350-37-1 |
Solubility (25°C) | 55.11 mg/L in Water |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Barış Yilmaz, et al. Cefixime-induced hepatotoxicity
[5] K G Naber. Cefixime in urinary tract infections. (Specific studies and literature review)
Related Antibiotic Products |
---|
Ningnanmycin
Ningnanmycin is a cytosine nucleoside peptide antibiotic, which is a highly effective, low-toxic, non-accumulative, broad-spectrum fungicide. |
Sulfacytine
Sulfacytine is a short-acting sulfonamide antibiotic. |
Cefcapene pivoxil hydrochloride
Cefcapene pivoxil hydrochloride, the pivalate ester precursor form of Cefcapene, is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) research. |
Kendomycin
Kendomycin is a polyketide antibiotic with significant antibacterial activity and tumor cytotoxicity. At low concentrations (MIC: 5 μg/mL), Kendomycin inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) strain COL. In addition, Kendomycin is an endothelin receptor antagonist and calcitonin receptor agonist. |
Ceftobiprole
Ceftobiprole is a broad-spectrum cephalosporin with rapid bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Gram-negative bacteria, with a MIC90 value of 2 μg/mL against MRSA. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.