Cefepime is a semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefepime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
| Molecular Weight | 480.56 |
| Formula | C19H24N6O5S2 |
| CAS Number | 88040-23-7 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Gozun Maan, et al. J Antimicrob Chemother. Cefepime-induced neurotoxicity: systematic review
[4] Jennifer Muradbegovic, et al. Rev Med Suisse. [Cefepime-induced encephalopathy]
[5] Danielle McDonald, et al. Am J Perinatol. Cefepime Dosing in Neonates: What is the Evidence?
| Related Antibiotic Products |
|---|
| TH-Z145
TH-Z145 is a lipophilic GGPPS inhibitor (GGPPS IC50 = 210 nM). TH-Z145 is a very lipophilic bisphosphonate that lacks the cationic center essential for FPPS inhibition and is thus a specific GGPPS inhibitor (FPPS IC50 >30 mM). TH-Z145 exhibited strong prophylactic effects in a pathogenic influenza model. |
| TH-Z93
TH-Z93, a lipophilic bisphosphonate, is an FPPS inhibitor (IC50 = 90 nM). TH-Z93 exhibits potent efficacy, increasing both antibody titers and avidity. TH-Z93 exhibited strong prophylactic effects in a pathogenic influenza model. |
| Ningnanmycin
Ningnanmycin is a cytosine nucleoside peptide antibiotic, which is a highly effective, low-toxic, non-accumulative, broad-spectrum fungicide. |
| Sulfacytine
Sulfacytine is a short-acting sulfonamide antibiotic. |
| Cefcapene pivoxil hydrochloride
Cefcapene pivoxil hydrochloride, the pivalate ester precursor form of Cefcapene, is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) research. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
