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Cefadroxil hydrate

Cat. No. M19940
Cefadroxil hydrate Structure
Size Price Availability Quantity
25mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.

Chemical Information
Molecular Weight 381.40
Formula C16H19N3O6S
CAS Number 66592-87-8
Solubility (25°C) DMSO 1.76 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Magali B Hickey, et al. J Pharm Sci. Hydrates and solid-state reactivity: a survey of beta-lactam antibiotics

[2] V P Lehto, et al. Pharm Res. Simultaneous determination of the heat and the quantity of vapor sorption using a novel microcalorimetric method

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