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Cefadroxil hydrate

Cat. No. M19940
Cefadroxil hydrate Structure
Size Price Availability Quantity
25mg USD 90  USD90 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 381.40
Formula C16H19N3O6S
CAS Number 66592-87-8
Purity >99%
Solubility DMSO 1.76 mg/mL
Storage at -20°C
References

[1] Magali B Hickey, et al. J Pharm Sci. Hydrates and solid-state reactivity: a survey of beta-lactam antibiotics

[2] V P Lehto, et al. Pharm Res. Simultaneous determination of the heat and the quantity of vapor sorption using a novel microcalorimetric method

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