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Ceefourin 1 

Cat. No. M29898

All AbMole products are for research use only, cannot be used for human consumption.

Ceefourin 1  Structure

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Biological Activity

Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma.

Chemical Information
Molecular Weight 294.42
Formula C11H10N4S3
CAS Number 315702-40-0
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ana Sahores, et al. Biochim Biophys Acta Gen Subj. Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine

[2] Edgardo Becerra, et al. Medicina (Kaunas). Specific MRP4 Inhibitor Ceefourin-1 Enhances Apoptosis Induced by 6-Mercaptopurine in Jurkat Leukemic Cells, but Not in Normal Lymphoblast Cell Line CRL-1991

[3] Robert Wolf, et al. Haematologica. Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets

[4] Edgardo Becerra, et al. Molecules. Study of Endogen Substrates, Drug Substrates and Inhibitors Binding Conformations on MRP4 and Its Variants by Molecular Docking and Molecular Dynamics

[5] Leanna Cheung, et al. Biochem Pharmacol. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)

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Keywords: Ceefourin 1  supplier, inhibitors, activators

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