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Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib, is a CDK inhibitor with antitumor activity.
| Molecular Weight | 494.54 |
| Formula | C25H28F2N8O |
| CAS Number | 2704316-81-2 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Ligands for Target Protein for PROTAC Products |
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| PD0325901-O-C2-dioxolane
PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader. |
| AP1867-2-(carboxymethoxy)
AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. |
| BTK ligand 1
BTK ligand 1 is a ligand targeting Bruton’s tyrosine kinase (Btk). |
| TSPO ligand-1
TSPO ligand-1 is the ligand of AUTAC4 that can be used in the synthesis of PROTACs. |
| PROTAC PTK6 ligand-1
PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation. |
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