Free shipping on all orders over $ 500

CC-90005

Cat. No. M21183
CC-90005  Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

CC-90005 is a potent, selective and orally active protein kinase C-θ (PKC-θ) inhibitor with an IC50 value of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation via IL-2 expression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 447.48
Formula C21H27F2N7O2
CAS Number 1799574-70-1
Purity >99%
Solubility DMSO : 62.5 mg/mL
Storage at -20°C
Related PKC Products
HA-100 dihydrochloride

HA-100 dihydrochloride is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase with IC50 of 4 μM, 8 μM, 12 μM and 240 μM, respectively.

PKC-theta inhibitor

PKC-theta inhibitor inhibits PKC-θ with an IC50 of 12 nM.

2-Methoxy-1,4-naphthoquinone

2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.

WAY-301398

WAY-301398 is a inhibitor of arylamine Nacetyltransferase.

WAY-332656

WAY-332656 is a inhibitor of Protein kinase C epsilon signaling.

  Catalog
Abmole Inhibitor Catalog




Keywords: CC-90005 supplier, PKC, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.