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Cathepsin B is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death). Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.
| CAS Number | 9047-22-7 |
| Form | Lyophilized powder |
| Storage | -20°C |
[2] J S Mort et al. Int J Biochem Cell Biol. Cathepsin B
[3] Olja Mijanović et al. Cancer Lett. Cathepsin B: A sellsword of cancer progression
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