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Carotegrast methyl

Cat. No. M11424
Carotegrast methyl Structure


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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Carotegrast Methyl (AJM300) is an orally effective and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast Methyl, is a specific dual α4β1/α4β7 integrin antagonist. Carotegrast Methyl prevents colitis in mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 569.44
Formula C28H26Cl2N4O5
CAS Number 401905-67-7
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
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Keywords: Carotegrast methyl, AJM300 supplier, Integrin, inhibitors

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