Free shipping on all orders over $ 500

Carebastine

Cat. No. M22131
Carebastine Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Carebastine

Chemical Information
Molecular Weight 499.6
Formula C32H37NO4
CAS Number 90729-42-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A De Luisi, et al. Eur Respir J. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling

[2] Y Zhao, et al. Clin Exp Dermatol. Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor

[3] Kwang-Hyeon Liu, et al. Drug Metab Dispos. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A

[4] I Tamai, et al. J Drug Target. Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine

[5] P Kingham. Curr Opin Investig Drugs. Carebastine Almirall Prodesfarma

Related Products
Isothiuronium

Isothiouronium is a functional group, it is the acid salt of isothiourea.

Sultosilic acid, piperazine salt

Sultosilic acid piperazine salt is a compound with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically significant decrease of triglycerides, total cholesterol, beta- and pre-beta-cholesterol and an increase of alpha-cholesterol.

Ipamorelin

Ipamorelin (NNC-26-0161) is a a novel and potent ghrelin mimetic peptide compound that counteracts glucocorticoid-induced decrease in bone formation of adult rats.

PRGL493

PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models.

Hercynine

Hercynine is a natural product, found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees, and is a precursor of L-(+)-ergothioneine.

  Catalog
Abmole Inhibitor Catalog




Keywords: Carebastine supplier, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.