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Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. Carbacyclin activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression in murine heart.
| Molecular Weight | 350.49 |
| Formula | C21H34O4 |
| CAS Number | 69552-46-1 |
| Form | Solid |
| Solubility (25°C) | Soluble in ethanol |
| Storage | Powder -20°C |
| Related Prostaglandin Receptor Products |
|---|
| Prostaglandin D2
Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. PGD2 plays a protective role by suppressing inflammation. |
| Tafluprost acid
Tafluprost acid (AFP-172) is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. |
| TG8-260
TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation. |
| Camonagrel
Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. |
| BAY 73-1449
BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. |
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