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Camellianin B

Cat. No. M18912
Camellianin B Structure
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Camellianin B

Chemical Information
CAS Number 109232-76-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yang Hu, et al. Org Biomol Chem. Synthetic investigation toward apigenin 5-O-glycoside camellianin B as well as the chemical structure revision

[2] Yunliang Zheng, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Pharmacokinetics and tissue distribution study of camellianin A and its major metabolite in rats by liquid chromatography with tandem mass spectrometry

[3] Wensong Zuo, et al. Zhongguo Zhong Yao Za Zhi. [Simultaneous determination of five flavonoid compounds in leaves of Adinandra nitida by HPLC-PAD]

[4] Benguo Liu, et al. Pharm Biol. Antioxidant and angiotensin converting enzyme (ACE) inhibitory activities of ethanol extract and pure flavonoids from Adinandra nitida leaves

[5] G R Cheng, et al. Yao Xue Xue Bao. [The structures of two new flavonoid glycosides from bai-shui-cha, a kind of Camellia sinensis L]

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