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Cadisegliatin (TTP-399)

Cat. No. M21626
Cadisegliatin (TTP-399) Structure


Size Price Availability
5mg USD 300  USD300 1-2 Weeks
10mg USD 480  USD480 1-2 Weeks
25mg USD 950  USD950 1-2 Weeks
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Quality Control & Documentation
Biological Activity

Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes. Cadisegliatin did not cause hypoglycemia, had no detrimental effect on plasma lipids or liver enzymes, and did not increase blood pressure, highlighting the importance of tissue selectivity and preservation of physiological regulation when targeting key metabolic regulators such as GK.

Chemical Information
Molecular Weight 455.63
Formula C21H33N3O4S2
CAS Number 859525-02-3
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Cadisegliatin (TTP-399), TTP-399 supplier, inhibitors, activators

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