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Cadazolid is a new antibiotic in development for the treatment of Clostridium difficile-associated diarrhea. Cadazolid is active against all (including linezolid- and moxifloxacin-resistant) Clostridium difficile strains (MIC90 0.125, range 0.03-0.25 mg/L). The cadazolid geometric mean MIC is 152-fold, 16-fold, 9-fold and 7-fold lower than those of moxifloxacin, linezolid, metronidazole and vancomycin, respectively. Both cadazolid dosing regimens rapidly reduce Clostridium difficile viable counts and cytotoxin with no evidence of recurrence.
| Cell Experiment | |
|---|---|
| Cell lines | C. difficile |
| Preparation method | Experiments to assess the effects of cadazolid and comparator antibiotics on C. difficile toxin formation were done by determination of toxin A and B concentrations in stationary-phase cultures of toxigenic C. difficile |
| Concentrations | 0.3% (vol/vol) DMSO |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Hamster model of CDAD |
| Formulation | 0.5% [wt/wt] methylcellulose containing 0.05% [wt/vol] Tween 80 |
| Dosages | 10 mg/kg |
| Administration | gavage |
| Molecular Weight | 505.55 |
| Formula | C29H29F2N3O8 |
| CAS Number | 1025097-10-2 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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