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Cat. No. M14104
CA-170 Structure
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Biological Activity

CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes.

Chemical Information
Molecular Weight 360.32
CAS Number 1673534-76-3
Solubility (25°C) DMSO 28.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Pottayil G Sasikumar, et al. PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacy

[2] Bogdan Musielak, et al. CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?

[3] Christine Cuyler, et al. Muskox status, recent variation, and uncertain future

[4] Raphal Paris, et al. Explosive eruption, flank collapse and megatsunami at Tenerife ca. 170 ka

[5] Toru Odate, et al. Anatomy of the levator claviculae, with an overview and a literature survey

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Keywords: CA-170 supplier, PD-1/PD-L1, inhibitors, activators

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