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CA-170

Cat. No. M14104

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CA-170 Structure
Size Price Availability Quantity
5mg USD 420  USD420 In stock
10mg USD 670  USD670 In stock
25mg USD 1300  USD1300 In stock
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Quality Control & Documentation
Biological Activity

CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes.

Chemical Information
Molecular Weight 360.32
CAS Number 1673534-76-3
Solubility (25°C) DMSO 28.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Pottayil G Sasikumar, et al. PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacy

[2] Bogdan Musielak, et al. CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?

[3] Christine Cuyler, et al. Muskox status, recent variation, and uncertain future

[4] Raphal Paris, et al. Explosive eruption, flank collapse and megatsunami at Tenerife ca. 170 ka

[5] Toru Odate, et al. Anatomy of the levator claviculae, with an overview and a literature survey

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Keywords: CA-170 supplier, PD-1/PD-L1, inhibitors, activators

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