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CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes.
| Molecular Weight | 360.32 |
| CAS Number | 1673534-76-3 |
| Solubility (25°C) | DMSO 28.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Bogdan Musielak, et al. CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?
[3] Christine Cuyler, et al. Muskox status, recent variation, and uncertain future
[4] Raphal Paris, et al. Explosive eruption, flank collapse and megatsunami at Tenerife ca. 170 ka
[5] Toru Odate, et al. Anatomy of the levator claviculae, with an overview and a literature survey
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