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c-Myc inhibitor 7

Cat. No. M45299

All AbMole products are for research use only, cannot be used for human consumption.

c-Myc inhibitor 7 Structure

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Quality Control & Documentation
Biological Activity

c-Myc inhibitor 7 is a c-Myc inhibitor and multi-targeted protein degrader. c-Myc inhibitor 7 effectively degrades c-Myc, CK1α, GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. It can also be used in the study of diseases with high c-Myc expression.

Chemical Information
Molecular Weight 614.65
Formula C35H30N6O5
CAS Number 2883535-99-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hongnan Mo, et al. Mol Cancer. S6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer

[2] Yuhong Luo, et al. Nat Metab. Intestinal MYC modulates obesity-related metabolic dysfunction

[3] Trang Thi Thu Nguyen, et al. J Clin Invest. HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models

[4] Jay Chauhan, et al. ChemMedChem. Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization

[5] Frank M Lehmann, et al. PLoS One. Humanized c-Myc mouse

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Keywords: c-Myc inhibitor 7 supplier, Casein Kinase, inhibitors, activators

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