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c-di-AMP (Cyclic diadenylate) is a STING agonist, it binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway. c-di-AMP (Cyclic diadenylate) signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
| Molecular Weight | 658.42 |
| Formula | C20H24N10O12P2 |
| CAS Number | 54447-84-6 |
| Solubility (25°C) | Water 3 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related STING Products |
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STING-IN-6 is a potent STING inhibitor with a pIC50 of 8.9. |
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Products are for research use only. Not for human use. We do not sell to patients.
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