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Bz 423 is a aTP synthase inhibitor (IC50 ~5 μM). Bz 423 binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Bz 423 kills primary B and T cell in mice in vivo. Bz 423 suppresses autoimmunity and prolongs survival in mouse lupus model.
| Molecular Weight | 440.92 |
| Formula | C27H21ClN2O2 |
| CAS Number | 216691-95-1 |
| Solubility (25°C) | DMSO 44 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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