Certificate of Analysis
| Product Name: | Bz 423 |
| Catalog Number: | M6551 |
| CAS Number: | 216691-95-1 |
Physical and Chemical Properties
| Formula: | C27H21ClN2O2 |
| Molecular Weight: | 440.92 |
| Solubility: | DMSO 44 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >98% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Bz 423 is a aTP synthase inhibitor (IC50 ~5 μM). Bz 423 binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Bz 423 kills primary B and T cell in mice in vivo. Bz 423 suppresses autoimmunity and prolongs survival in mouse lupus model. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |