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Butyzamide

Cat. No. M31173
Butyzamide Structure
Size Price Availability Quantity
5mg USD 600  USD600 In stock
10mg USD 1000  USD1000 In stock
25mg USD 1800  USD1800 In stock
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Quality Control & Documentation
Biological Activity

Butyzamide is a novel, potent, orally active activator of the non-peptidic thrombopoietin receptor (Mpl) that specifically reacts with human Mpl and activates the same signaling pathways as thrombopoietin. In addition, Butyzamide can be used for the expansion of human hematopoietic stem cells.

Chemical Information
Molecular Weight 591.55
Formula C29H32Cl2N2O5S
CAS Number 1110767-45-7
Form Solid
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Guixian Liang, et al. Cell Regen. Long-term expansion of human hematopoietic stem cells

[2] Masatoshi Sakurai, et al. Int J Hematol. In vivo expansion of functional human hematopoietic stem progenitor cells by butyzamide

[3] Alan T Nurden, et al. Lancet. New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura

[4] Wataru Nogami, et al. Haematologica. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis

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