Butyzamide is a novel, potent, orally active activator of the non-peptidic thrombopoietin receptor (Mpl) that specifically reacts with human Mpl and activates the same signaling pathways as thrombopoietin. In addition, Butyzamide can be used for the expansion of human hematopoietic stem cells.
| Molecular Weight | 591.55 |
| Formula | C29H32Cl2N2O5S |
| CAS Number | 1110767-45-7 |
| Form | Solid |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Guixian Liang, et al. Cell Regen. Long-term expansion of human hematopoietic stem cells
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