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Cat. No. M20918
Butoconazole Structure
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Biological Activity

Butoconazole is an imidazole antifungal used in gynecology.

Chemical Information
Molecular Weight 411.78
Formula C19H17Cl3N2S
CAS Number 64872-76-0
Solubility (25°C) DMSO 82 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Bianca-Maria Ţuchiu, et al. ACS Omega. N-Methylfulleropyrrolidine-Based Multimode Sensor for Determination of Butoconazole Nitrate

[2] No authors listed. Butoconazole

[3] D Brown, et al. J Reprod Med. Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group

[4] D M Tatum, et al. Infect Control Hosp Epidemiol. Butoconazole nitrate

[5] R H Kaufman, et al. J Reprod Med. Comparison of three-day butoconazole treatment with seven-day miconazole treatment for vulvovaginal candidiasis

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Keywords: Butoconazole supplier, Anti-infection, inhibitors, activators

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