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Butenafine

Cat. No. M20946
Butenafine Structure
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Quality Control & Documentation
Biological Activity

Butenafine is a synthetic benzylamine antifungal agent.

Chemical Information
Molecular Weight 317.47
Formula C23H27N
CAS Number 101828-21-1
Solubility (25°C) DMSO 63 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Adriana Bezerra-Souza, et al. J Immunol Res. Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis

[2] No authors listed. Butenafine

[3] Archana Singal. Expert Opin Drug Metab Toxicol. Butenafine and superficial mycoses: current status

[4] T A Syed, et al. Expert Opin Pharmacother. Butenafine hydrochloride: for the treatment of interdigital tinea pedis

[5] W McNeely, et al. Drugs. Butenafine

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