Bucillamine is an orally bioavailable endogenous derivative of the amino acid cysteine with potential antioxidant and anti-inflammatory activity. Upon oral administration, Bucillamine rapidly enters cells via the same pathway as cysteine, complementing the thiol groups in glutathione ( GSH ), thereby increasing intracellular GSH levels and GSH activity.GSH is an antioxidant that plays an important protective role in oxidative stress and injury.
|Storage||4°C, protect from light|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Anti-infection Products|
AV5124 is a Cap-dependent endonuclease (CEN) inhibitor for studies related to respiratory diseases.
ML188 is a first-in-class probe and also a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. antiviral activity.
Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.
|Neochlorogenic acid methyl ester
Neochlorogenic acid methyl ester (5-O-Caffeoylquinic acid methyl ester) is an HBV inhibitor.
Methyl tanshinonate is a potent inhibitor of Mpro enzyme in SARS-CoV (IC50 = 21.1 µM).
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