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BTB06584

Cat. No. M2474
BTB06584 Structure
Size Price Availability Quantity
10mg USD 80  USD80 In stock
50mg USD 180  USD180 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 417.82
Formula C19H12ClNO6S
CAS Number 219793-45-0
Purity >98%
Solubility DMSO 70 mg/mL
Storage at -20°C
References

[1] Daniela Strobbe, et al. NH-sulfoximine: A novel pharmacological inhibitor of the mitochondrial F 1 F o -ATPase, which suppresses viability of cancerous cells

[2] Yupei Wang, et al. Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation

[3] Yupei Wang, et al. Selective ATP hydrolysis inhibition in F1Fo ATP synthase enhances radiosensitivity in non-small-cell lung cancer cells (A549)

[4] Ivana Matic, et al. Controlled and Impaired Mitochondrial Quality in Neurons: Molecular Physiology and Prospective Pharmacology

[5] Fabrice Ivanes, et al. The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase

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