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Brompheniramine is a histamine H1 receptors antagonist. Brompheniramine also functions as a moderately effective anticholinergic agent, and is likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Brompheniramine is an antihistamine compound of the propylamine (alkylamine) class. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin.Brompheniramine also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 percent. Brompheniramine is metabolised by cytochrome P450s.
| Molecular Weight | 435.31 |
| Formula | C16H19BrN2.C4H4 |
| CAS Number | 980-71-2 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] J W THOMAS. Para-bromdylamine maleate (dimetane); a clinical evaluation: report of 140 cases
| Related Histamine Receptor Products |
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| Dimethindene
Dimethindene is a potent, selective histamine H1 antagonist. |
| ABT-288
ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. |
| A-349821
A-349821 is a histamine H3 receptor antagonist characterized as a radioligand ([3H]-A-349821) for in vivo receptor occupancy assessment. |
| Betazole
Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. |
| Tiotidine
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). |
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