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Brilacidin tetrahydrochloride

Cat. No. M27977

All AbMole products are for research use only, cannot be used for human consumption.

Brilacidin tetrahydrochloride Structure
Synonym:

PMX 30063 tetrahydrochloride

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Quality Control & Documentation
Biological Activity

Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is an anti-infective antimicrobial with MIC90s of 1 and 8 μg/mL for Gram-positive bacteria Streptococcus pneumonia and Streptococcus viridans, and MIC90 of 8 and 4 μg/mL for Gram-negative bacteria Haemophilus influenza and Pseudomonas aeruginosa. Brilacidin tetrahydrochloride is a defensin mimetic antibiotic compound.

Chemical Information
Molecular Weight 1082.75
Formula C40H54Cl4F6N14O6
CAS Number 1224095-99-1
Form Solid
Solubility (25°C) DMSO 83.33 mg/mL (ultrasonic)
Storage 4°C, dry, sealed
References

[1] Chuan Xu, et al. EC Microbiol. Brilacidin, a Non-Peptide Defensin-Mimetic Molecule, Inhibits SARS-CoV-2 Infection by Blocking Viral Entry

[2] Yanmei Hu, et al. J Med Virol. Brilacidin, a COVID-19 drυg candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell

[3] Allison Bakovic, et al. Viruses. Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture

[4] Regis P Kowalski, et al. J Ocul Pharmacol Ther. An Independent Evaluation of a Novel Peptide Mimetic, Brilacidin (PMX30063), for Ocular Anti-infective

[5] Bruk Mensa, et al. Antimicrob Agents Chemother. Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16

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Keywords: Brilacidin tetrahydrochloride, PMX 30063 tetrahydrochloride supplier, Antibiotic, inhibitors, activators

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