Free shipping on all orders over $ 500

Brilacidin tetrahydrochloride

Cat. No. M27977

All AbMole products are for research use only, cannot be used for human consumption.

Brilacidin tetrahydrochloride Structure
Synonym:

PMX 30063 tetrahydrochloride

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is an anti-infective antimicrobial with MIC90s of 1 and 8 μg/mL for Gram-positive bacteria Streptococcus pneumonia and Streptococcus viridans, and MIC90 of 8 and 4 μg/mL for Gram-negative bacteria Haemophilus influenza and Pseudomonas aeruginosa. Brilacidin tetrahydrochloride is a defensin mimetic antibiotic compound.

Chemical Information
Molecular Weight 1082.75
Formula C40H54Cl4F6N14O6
CAS Number 1224095-99-1
Form Solid
Solubility (25°C) DMSO 83.33 mg/mL (ultrasonic)
Storage 4°C, dry, sealed
References

[1] Chuan Xu, et al. EC Microbiol. Brilacidin, a Non-Peptide Defensin-Mimetic Molecule, Inhibits SARS-CoV-2 Infection by Blocking Viral Entry

[2] Yanmei Hu, et al. J Med Virol. Brilacidin, a COVID-19 drυg candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell

[3] Allison Bakovic, et al. Viruses. Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture

[4] Regis P Kowalski, et al. J Ocul Pharmacol Ther. An Independent Evaluation of a Novel Peptide Mimetic, Brilacidin (PMX30063), for Ocular Anti-infective

[5] Bruk Mensa, et al. Antimicrob Agents Chemother. Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16

Related Antibiotic Products
Puromycin-d3

Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

BSH-IN-1

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.

AAA-10

AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively.

Gut restricted-7

Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice.

N-Hydroxypipecolic acid

N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection.

  Catalog
Abmole Inhibitor Catalog




Keywords: Brilacidin tetrahydrochloride, PMX 30063 tetrahydrochloride supplier, Antibiotic, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.