Free shipping on all orders over $ 500


Cat. No. M14317
Brensocatib Structure

AZD7986; INS 1007

Size Price Availability Quantity
5mg USD 198  USD198 In stock
10mg USD 345  USD345 In stock
50mg USD 1180  USD1180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Brensocatib (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively.

Chemical Information
Molecular Weight 420.46
CAS Number 1802148-05-5
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Xiao Bao Shen, et al. Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities

[2] Robert Palmr, et al. Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure-Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

[3] James D Chalmers, et al. Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

[4] Lijuan Sun, et al. Activating a collaborative innate-adaptive immune response to control metastasis

[5] Daniela F Quail, et al. Neutrophil phenotypes and functions in cancer: A consensus statement

Related Dipeptidyl Peptidase Products

Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity.

Sitagliptin fenilalanil hydrochloride

Sitagliptin fenilalanil hydrochloride is a dipeptidyl aminopeptidase 4 (DPP-4) inhibitor.


Lys-Ala-pNA is hydrolytic substrate the of dipeptidyl peptidase (DPP) II with Km of 0.42 mM.


γ-Glu-Tyr, a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC50=6.77 mM), is a potentially functional component of the type 2 diabetes diet.

Saikogenin A

Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

Abmole Inhibitor Catalog

Keywords: Brensocatib, AZD7986; INS 1007 supplier, Dipeptidyl Peptidase, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.