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Brassinin

Cat. No. M8592

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Brassinin Structure

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Quality Control & Documentation
Biological Activity

Brassinin is a phytoalexin isolated from cruciferous vegetables that exhibits anticancer, chemopreventive, antiproliferative and antifungal activities. In lung cancer cells, brassinin inhibits constitutive and IL-6-inducible STAT3 signaling through modulation of PIAS-3 and SOCS-3. It appears that brassinin induces apoptosis in PC-3 prostate cancer cells via the suppression of PI3K/Akt/mTOR/S6K1 signaling.

Chemical Information
Molecular Weight 236.36
Formula C11H12N2S2
CAS Number 105748-59-2
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Min Hee Yang, et al. Brassinin enhances the anticancer actions of paclitaxel by targeting multiple signaling pathways in colorectal cancer cells

[2] Taeyeon Hong, et al. Brassinin Inhibits Proliferation in Human Liver Cancer Cells via Mitochondrial Dysfunction

[3] Guillaume Quang N'Guyen, et al. Responses of the Necrotrophic Fungus Alternaria brassisicola to the Indolic Phytoalexin Brassinin

[4] Bobin Kang, et al. Brassinin, a brassica-derived phytochemical, regulates monocyte-to-macrophage differentiation and inflammatory responses in human monocytes and murine macrophages

[5] M Soledade C Pedras, et al. Methoxycamalexins and related compounds: Syntheses, antifungal activity and inhibition of brassinin oxidase

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