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BQCA is a potent muscarinic M1 receptor positive allosteric regulator with higher selectivity to M1 than M2-M5. It enhances M1 activity in vitro and in vivo trials and has oral bioavailability. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including the hippocampus, cortex, and striatum. BQCA binds to M1 in a allosteric manner, enhancing the binding and potency of ACh on the receptor. M1 activation is a proposed mechanism for increasing information processing in disease states such as Alzheimer's disease. M1 agonists are currently being investigated as potential compounds for the study of cognitive and negative symptoms in Alzheimer's disease and schizophrenia. BQCA has been shown to improve performance on cognitive tasks and increase brain blood flow.
| Molecular Weight | 309.32 |
| Formula | C18H15NO4 |
| CAS Number | 338747-41-4 |
| Solubility (25°C) | DMSO: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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