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Boc-L-proline

Cat. No. M38906
Boc-L-proline Structure
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Biological Activity

Boc-L-proline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Information
Molecular Weight 215.25
Formula C10H17NO4
CAS Number 15761-39-4
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Eavan C McLoughlin et al. Bioorg Chem. Synthesis by diastereomeric resolution, biochemical evaluation and molecular modelling of chiral 3-hydroxyl b-lactam microtubule-targeting agents for the treatment of triple negative breast and chemoresistant colorectal cancers

[2] Eavan C McLoughlin et al. ChemistryOpen. Application of 2D EXSY and qNMR Spectroscopy for Diastereomeric Excess Determination Following Chiral Resolution of β-Lactams

[3] Ana Marzo-Mas et al. Med Chem. N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents

[4] Sivasankaran Dhanasekaran et al. J Org Chem. Enantioselective A3-Coupling Reaction Employing Chiral CuI- iPrpyboxdiPh/ N-Boc-(l)-Proline Complex under Cooperative Catalysis: Application in the Synthesis of (Indol-2-yl)methanamines

[5] Hajime Seki et al. European J Org Chem. Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component

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