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BNS-22 is a derivative of natural product GUT-70 isolated from the stem bark of Calophyllum brasiliense exhibits antiproliferative activity against human cancer cells. It appears that BNS-22 is a specific DNA-topoisomerase II (TOPO2) catalytic inhibitor. BNS-22 does not induce DNA damage.
| Molecular Weight | 407.46 |
| Formula | C24H25NO5 |
| CAS Number | 1151668-24-4 |
| Solubility (25°C) | DMSO: 2 mg/mL warmed |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Makoto Kawatani, et al. Chemical biology and novel molecular-targeted agents in cancer therapy
[3] Shinya Kimura. Possibility of the natural product extracted from Calophyllum Brasiliense
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