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BMSpep-57 

Cat. No. M31224

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BMSpep-57  Structure
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Biological Activity

BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs.

Chemical Information
Molecular Weight 1868.17
Formula C89H126N24O19S
CAS Number 1629655-80-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aravindhan Ganesan, et al. Sci Rep. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

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Keywords: BMSpep-57  supplier, PD-1/PD-L1, inhibitors, activators

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