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BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs.
| Molecular Weight | 1904.63 |
| Formula | C89H127ClN24O19S |
| CAS Number | 1629655-80-6 (free base) |
| Form | Solid |
| Storage | Store at ≤ -20°C, dry, sealed |
| Related PD-1/PD-L1 Products |
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PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model. |
| NSC622608
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| PD-L1-IN-1
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| SL-279252
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