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BMS-986202

Cat. No. M21298

All AbMole products are for research use only, cannot be used for human consumption.

BMS-986202  Structure

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Quality Control & Documentation
Biological Activity

BMS-986202 is a potent, selective, orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 of 14 μM. BMS-986202 can be used in IL-23-driven echinococcosis BMS-986202 can be used in studies of IL-23-driven echinococcosis, anti-CD40-induced colitis and spontaneous lupus.

Chemical Information
Molecular Weight 439.46
Formula C22H18D3FN6O3
CAS Number 1771691-34-9
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chunjian Liu, et al. J Med Chem. Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2

[2] Jonathan Ellery, et al. Eur J Pharmacol. Identification of compounds acting as negative allosteric modulators of the LPA1 receptor

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  Catalog
Abmole Inhibitor Catalog




Keywords: BMS-986202 supplier, JAK, inhibitors, activators

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