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BMS-986122

Cat. No. M11311
BMS-986122  Structure
Synonym:

BMS986122, BMS 986122

Size Price Availability Quantity
5mg USD 155  USD155 In stock
10mg USD 285  USD285 In stock
25mg USD 560  USD560 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Bms-986122 is a selective and effective positive allosteric regulator of μ -opioid receptor (µ-OR). Bms-986122 showed enhancement of β -inhibitory protein recruitment, adenylate cyclase inhibition and G-protein activation mediated by normal agonists. Bms-986122 enhances damGO-mediated [35S]GTPγS binding in mouse meninges.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 448.78
Formula C16H15BrClNO3S2
CAS Number 313669-88-4
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage 2-8°C
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  Catalog
Abmole Inhibitor Catalog




Keywords: BMS-986122 , BMS986122, BMS 986122 supplier, Opioid Receptor, inhibitors

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