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BMS-599626 Hydrochloride

Cat. No. M14133
BMS-599626 Hydrochloride Structure
Synonym:

AC480 Hydrochloride

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 567.01
Formula
CAS Number 873837-23-1
Purity >99%
Solubility DMSO 90 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Joan Albanell, et al. Curr Drug Targets. Small molecules with EGFR-TK inhibitor activity

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Keywords: BMS-599626 Hydrochloride, AC480 Hydrochloride supplier, EGFR/HER2, inhibitors

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